Steroid Derivatives as Potential Antimicrobial Agents against Staphylococcus aureus Planktonic Cells

Steroid Derivatives as Potential Antimicrobial Agents against Staphylococcus aureus Planktonic Cells

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In this work, the antibacterial activity of deflazacort and several of its synthetic precursors was tested against a panel of bacterial pathogens responsible for most drug-resistant infections including Staphylococcus aureus, Enterococcus spp., Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp.The derivative of deflazacort, PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) showed the best antibacterial activity in a here dose-dependent way.

We focused on the action of PYED-1 against S.aureus cells.PYED-1 exhibited an additive antimicrobial effect with gentamicin and oxacillin against the methicillin-resistant S.

aureus isolate 00717.In addition here to its antimicrobial effect, PYED-1 was found to repress the expression of several virulence factors of S.aureus, including toxins encoded by the hla (alpha-haemolysin), hlb (beta-haemolysin), lukE-D (leucotoxins E-D), and sea (staphylococcal enterotoxin A) genes, and cell surface factors (fnbB (fibronectin-binding protein B) and capC (capsule biosynthesis protein C)).

The expression levels of autolysin isaA (immunodominant staphylococcal antigen) were also increased.